麻的抗炎作用 (西博尔德和扎克) 终结的终结 终结的终结 叶子精油 叶子精油
Sung-Hee Kim1, Young-Ah Jang2, Yong-Jin Kwon1,3
1Department of Cosmeceutical Science, Kyungsung University, Busan 48434, Republic of Korea.
Molecules (Basel, Switzerland)
|March 13, 2024
概括
查梅西帕里斯 obtusa叶精油 (COD) 和sabinene通过抑制巨细胞的关键信号通路来减少炎症. 这项研究强调了它们的潜在治疗益处.
科学领域:
- 植物化学 植物化学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 黑 (Chamaecyparis obtusa) 是一种原产于东亚的植物,因其美观和药用特性而被广泛利用.
- 来自C. obtusa的精油含有各种化合物,但对活性成分的详细分析是有限的.
- 了解C. obtusa提取物的抗炎潜力对于治疗应用至关重要.
研究的目的:
- 为了分析C. obtusa叶精油 (COD) 中的sabinene含量.
- 为了比较COD和纯Sabinene的抗炎作用.
- 阐明其抗炎作用背后的分子机制.
主要方法:
- 气色谱-质谱 (GC-MS) 用于精油分析.
- 细胞活力测定 (MTT),氧化 (NO) 测量 (格雷斯试剂).
- RT-qPCR,用于基因和蛋白质表达的西部斑,用于分泌的细胞因子的细胞因子阵列.
主要成果:
- 在LPS诱导的RAW 264.7细胞中,COD和sabinene都抑制了可诱导的氧化合成酶 (iNOS) 和MAPK酸化 (JNK,p38).
- 在COD和sabinene中减少了促炎性细胞因子 (IL-1β,IL-6,IL-27,IL-1ra,GM-CSF).
- COD抑制了MAPKs和JAK/STAT轴,而sabinene抑制了MAPKs,两者都阻止了巨细胞的激活.
结论:
- C. obtusa叶精油及其组成部分sabinene具有显著的抗炎性质.
- 它们的机制包括抑制炎症信号通路,包括MAPK和JAK/STAT.
- 这些发现支持C. obtusa提取物在炎症条件下的治疗潜力.
相关概念视频
01:26Cholinergic Antagonists: Therapeutic Uses
746
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
746
01:19Antiasthma Drugs: Leukotriene Modifiers
297
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
297
01:11Direct-Acting Cholinergic Agonists: Therapeutic Uses
735
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
735
01:28Cholinergic Antagonists: Pharmacological Actions
1.1K
Antimuscarinic drugs block muscarinic receptors in multiple systems, including the gut, eye, smooth muscles, respiratory tract, cardiovascular, and central nervous systems. They produce similar effects with varying selectivity depending on the specific agent and tissue. Here are the key pharmacological actions of antimuscarinics:
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
1.1K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
294
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
294
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
670
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
670