合成,晶体结构,基因毒性,以及Ni (II) 和Cd (II) 皮拉胺协调复合物的抗真菌和抗菌研究
Amal El Mahdaoui1, Smaail Radi1, Youssef Draoui1
1LCAE, Department of Chemistry, Faculty of Sciences, University Mohammed I, Oujda 60000, Morocco.
Molecules (Basel, Switzerland)
|March 13, 2024
概括
两种基于pirazole的新型协调复合物表现出强大的抗真菌和抗Fusarium活性. 虽然连接物具有低基因毒性,但复合物具有增加的基因毒性,这表明需要进一步的安全评估.
科学领域:
- 生物有机化学 生物有机化学
- 药用化学 医学化学
- 协调化学 协调化学
背景情况:
- 基于皮拉的配体对于开发新型协调复合体至关重要.
- 研究金属复合物的生物无机性质是治疗应用的关键.
- 抗真菌和基因毒性评估对于药物开发至关重要.
研究的目的:
- 合成和描述基于皮拉的新型协调复合物.
- 评估这些复合物的抗真菌和抗菌活性.
- 评估合成的配体及其相应复合物的基因毒性.
主要方法:
- 基于皮拉的配体的合成:1,5-二甲基-N--1H-皮拉-3-碳胺 (L) 和1,5-二甲基-N--1H-皮拉-3-碳胺 (L).
- 结晶学分析以确定单核[Ni(L) ]2[ClO4) 2 (C) 和双核[Cd2 (L) ]2Cl4 (C) 复合物的结构.
- 在实验室中对抗真菌和抗Fusarium活性进行了评估,与循环赫西米德相比.
- 对配体 (L,L) 和复合体 (C,C) 的基因毒性测试.
主要成果:
- 两种协调复合物的成功合成和结构阐明.
- 对于复合体来说,已证明具有高度竞争力的抗真菌和抗菌活动.
- 干L和L表现出最小的基因毒性.
- 协调复合体C和C显示出显著的基因毒性增加.
结论:
- 合成的基于pyrazole的协调复合物具有显著的抗真菌和抗Fusarium特性.
- 虽然连接体是安全的,但复合物的增加基因毒性需要进一步调查.
- 这些发现突出了基于pyrazole的金属复合物的潜力和安全考虑在生物无机应用中.
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