甲状腺刺的营养和生理性质:在体外研究中使用便发酵和肠道完整性模型
Mohamad Khalil1, Francesca Piccapane2, Mirco Vacca3
1Clinica Medica "A. Murri", Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari Medical School, 70124 Bari, Italy.
Nutrients
|March 13, 2024
概括
Thymbra spicata是一种地中海植物,显示出作为肠道健康营养素的潜力. 它的化合物可能会对肠道微生物群和肠道屏障功能产生积极影响,尽管消化会影响有效性.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 地中海植物,如Thymbra spicata,以其健康益处而闻名.
- 在胃肠道上T. spicata的营养和生理影响仍然在很大程度上未被描述.
研究的目的:
- 为了描述T. spicata叶的营养成分.
- 研究T. spicata与胃肠道的生理相互作用,包括它对肠道微生物群和肠道完整性的影响.
主要方法:
- 营养分析,乙醇提取,模拟胃肠道消化和T. spicata叶的无氧肠道发酵.
- 使用Ussing室中的Caco-2细胞单层评估化合物,激素清除活性,挥发性有机化合物 (VOC) 和肠道完整性.
主要成果:
- 刺虫含有丰富的纤维 (12.3%) 和不和脂肪酸 (76%).
- 肠道发酵改变了VOC,包括短链脂肪酸,但没有影响微生物的生存能力.
- T. spicata及其主要化合物,卡瓦克罗尔,在Caco-2细胞中增强了离子电流,保持了单层完整性.
结论:
- T. spicata显示出作为调节肠道微生物群和肠道屏障的营养素的潜力.
- 通过模拟消化,T. spicata的有益作用的有效性降低,并通过结肠发酵取消,与多和卡瓦克罗尔含量相关联.
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