作为一个潜在的预测者在Primigravida早产:初步调查的孕产妇的基卡尼丁破坏:初步调查
Ying-Chieh Han1, Katarina Laketic1, Kylie K Hornaday2,3
1Department of Biomedical Engineering, Faculty of Engineering, University of Calgary, 2500 University Dr. NW, Calgary, AB T2N 1N4, Canada.
Nutrients
|March 13, 2024
概括
孕产妇的新陈代谢障碍,包括较低的甲和氨基酸代谢产物,与首次孕产妇的早产有关. 丁甲尼丁显示出预测早产风险的潜力.
科学领域:
- 生殖医学 生殖医学
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 过早分娩 (怀孕37周之前) 对母亲和婴儿构成重大健康风险.
- 虽然已知风险因素,但母亲的新陈代谢和早产之间的联系,特别是第一次母亲的情况,尚不清楚.
研究的目的:
- 为了识别与早产相关的母亲代谢变化.
- 评估这些代谢变化对早产的预测能力.
主要方法:
- 使用液体染色学/质谱法 (LC/MS) 对母体血清进行非向的代谢学分析.
- 血清样本从孕期前期和孕期出生的母亲在妊娠的第三季度 (怀孕28-32周) 收集.
- 代谢物识别使用了人类代谢基数据库 (HMDB),统计分析包括部分最小平方差异分析 (PLS-DA).
主要成果:
- 根据181种已识别的代谢物 (CV-ANOVA,p = 0.02) 观察到早产和终产群体之间存在明显的分离.
- 经历过早产的母亲表现出较低的血清水平的特定的甲和氨基酸代谢产物.
- 丁甲尼丁 (C4:1) 成为最具预测力的代谢物,用于早产 (AUROC = 0.73).
结论:
- 研究结果表明,早产母亲的脂肪酸氧化和能量代谢受损.
- 改变的代谢途径,指的是特定的代谢物,可以作为预测标志物,用于早产在primigravida.
- 需要进一步验证以确认这些代谢关联及其预测价值.
关键词:
脂肪酸脂肪酸是一种脂肪酸.质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量代谢 代谢 代谢 代谢代谢生物组的代谢生物组预测建模预测建模怀孕 怀孕 怀孕 怀孕 怀孕这就是为什么Primigravida是最重要的.查检查 查检查 查检查 查检查更多相关视频
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
3.8K
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.3K
相关概念视频
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
01:20Pathophysiology of Diabetes
927
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
927