24小时尿液糖生物标记在一个自动售货机摄入模式在一个多元化的人口
Mary M Ahern1, Emma J Stinson1, Susanne B Votruba1
1Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
Nutrients
|March 13, 2024
概括
总糖摄入量的新生物标志物显示,在不同人群中,与饮食摄入量有显著的关联. 这种24小时的尿糖和果糖生物标志物虽然有中等相关性,但为流行病学研究提供了有前途的工具.
科学领域:
- 营养流行病学 营养流行病学
- 生物标志物开发 生物标志物开发
- 公共卫生 营养 公共卫生 营养
背景情况:
- 准确测量饮食糖的摄入量对于了解其对健康的影响至关重要.
- 在大型研究中评估糖摄入量的现有方法存在局限性.
- 开发了一种用于总糖摄入量的新生物标志物.
研究的目的:
- 评估一种新的生物标志物对总糖摄入量的有效性.
- 在任意饮食条件下 (自选) 在不同人群中测试生物标志物.
主要方法:
- 63名健康的成年人 (包括美国原住民/阿拉斯加原住民) 参与了为期10天的住院研究.
- 通过自动售货机模式,在3天内评估饮食摄入量.
- 每天测量24小时尿中的糖和果糖分泌量 (24hruSF生物标志物).
主要成果:
- 24hruSF生物标志物与总糖摄入量之间存在中等相关性 (r = 0.33,p = 0.01).
- 在女性,年轻人,美洲原住民和正常的BMI类别中观察到更强的相关性.
- 一个线性混合模型证实了生物标志物和总糖摄入量之间的显著关联,解释了31%的差异.
结论:
- 24hruSF生物标志物与不同人群中糖的总摄入量有显著的关系.
- 在流行病学研究中评估饮食糖摄入量的生物标志物的实用性得到了支持.
- 在不同的人口分组中,相关性强度有所不同,这表明有针对性的应用或进一步改进的潜力.
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