餐后微量营养素的变化和生物可用性:年轻人与老年参与者的干预性饮食研究
Denny Pellowski1,2,3, Paula Kusch1,4, Thorsten Henning1,4,5,6
1Department Food Chemistry, Institute of Nutritional Science, University of Potsdam, 14469 Potsdam, Germany.
Nutrients
|March 13, 2024
概括
这项研究研究了年龄如何影响饭后微量营养素的吸收. 虽然一些营养因年龄而异,但个体差异最为显著,突出了个性化的营养需求.
科学领域:
- 营养科学 营养科学
- 人体生理学 人体生理学
- 老年学是指老年学的学科.
背景情况:
- 微量营养素的吸收和新陈代谢可以随着年龄的增长而改变.
- 了解这些变化对于保持老年人的健康至关重要.
- 生物梅尔研究调查了老年人微量营养素的生物可用性.
研究的目的:
- 探索食后微量营养素吸收的年龄和时间依赖的变化.
- 为了比较年轻和老年健康的成年人关于微量营养素水平和动态.
- 为了确定受年龄和饮食摄入量影响的特定微量营养素.
主要方法:
- 对43名健康参与者的分析 (年轻人与老年人).
- 血清/血微量营养素的量化 (Fe,Cu,Zn,Se,I,维生素C,视网醇,甘,胡卜素,托科菲醇,25(OH) 维生素D) 在基线和食后 (90-360分钟).
- 年龄组之间的基线度和食后变化的比较.
主要成果:
- 年轻的成年人有更高的血清和血中毒素的基线.
- 较老的成年人显示出更高的基线铜,,25(OH) 维生素D和多科菲醇.
- 食后,维生素C和柳科的变化依赖时间;,铜和显示了与年龄相关的代谢差异.
- 个体性解释了微量营养素水平的大部分观察到的差异.
结论:
- 年龄和时间影响食后微量营养素代谢,但个体的变化是主要因素.
- 研究结果提供了有关年龄的微量营养素动态的见解.
- 结果可以告知有针对性的干预措施,以防止老年人的缺陷.
相关概念视频
Bioavailability: Influencing Factors
Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
Bioavailability Study Design: Absolute Versus Relative Bioavailability
Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
Bioavailability Study Design: Single Versus Multiple Dose Studies
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...


