更年期热点和分子机制由食物来源的营养素调节
Ewa Forma1, Karina Urbańska2, Magdalena Bryś1
1Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Nutrients
|March 13, 2024
概括
本综述探讨了影响更年期妇女发热的分子因素和食物化合物. 某些营养素可以通过调节关键信号通路来提供自然缓解.
科学领域:
- 生殖生物学和分子营养学.
- 研究更年期血管运动症状的分子基础.
背景情况:
- 热的确切原因,一个常见的绝经症状,仍然不清楚,但涉及复杂的分子和遗传因素.
- 饮食营养素和生物活性化合物与细胞代谢相互作用,并与这些症状相关的信号通路交互.
研究的目的:
- 审查最近的文献 (过去5年) 关于分子因素和信号通路涉及更年期热.
- 从食物来源中识别潜在的天然治疗剂,可以缓解这些症状.
主要方法:
- 文献综述侧重于全基因组关联研究 (GWAS) 和分子途径.
- 对食品化合物影响已确定途径的实验数据的分析.
主要成果:
- 已确定的关键途径包括kisspeptin-GnRH,脂肪细胞激素,基碳化合物受体,雌激素代谢,炎症,氧化应激和葡萄糖的可用性.
- 特定的食品化合物和成分显示出调节这些通路的潜力.
结论:
- 了解热的分子基础可以指导自然干预的识别.
- 针对特定分子通路的饮食策略可以有效地缓解更年期血管运动症状.
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