预防性维生素D补充和COVID-19感染风险:系统性审查和元分析
Marina Sartini1,2, Filippo Del Puente3, Martino Oliva1
1Department of Health Sciences, University of Genoa, 16132 Genoa, Italy.
Nutrients
|March 13, 2024
概括
预防性维生素D补充剂显著减少了COVID-19的发生率和重症监护室 (ICU) 的入院. 这一元分析证实了维生素D的存在.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 维生素D对于免疫功能,骨健康和新陈代谢至关重要.
- 随着COVID-19大流行,人们开始研究维生素D在病毒免疫力中的作用.
- 了解维生素D对抗COVID-19的预防潜力至关重要.
研究的目的:
- 对维生素D补充剂的预防作用进行系统审查和元分析.
- 评估维生素D在减少COVID-19发病率,死亡率和重症监护室 (ICU) 入院方面的作用.
- 评估维生素D与COVID-19之间的保护性关联.
主要方法:
- 在PubMed/MEDLINE,Scopus,Cochrane和谷歌学者数据库中进行全面的文献搜索.
- 包括16个出版物进行元分析,并进行独立的选和质量评估.
- 使用95%信心区间 (CI) 计算几率比率 (OR) 来衡量效应的大小.
主要成果:
- 维生素D补充剂在随机对照试验中显示出对COVID-19发病率的保护作用 (OR 0.403,95% CI 0.218-0.747).
- 在分析性研究中,对COVID-19发病率观察到显著的保护作用 (OR 0.592,95% CI 0.476-0.736).
- 维生素D补充与ICU入院减少有关 (OR 0.317,95% CI 0.147-0.680).
结论:
- 维生素D补充剂在预防COVID-19发病率方面发挥着显著的保护作用.
- 维生素D摄入量与严重的COVID-19风险降低有关,需要接受ICU治疗.
相关概念视频
Role of Skin in Vitamin D Synthesis
5.2K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.2K
Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Pulmonary Tuberculosis I
242
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
242
Transmission-based Precautions II: Airborne and Protective Environment
1.3K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.3K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K


