针对氧化压力相关代谢综合征的肠道微生物群的营养方法:专注于早期生命编程
You-Lin Tain1,2,3, Chien-Ning Hsu4,5
1Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Nutrients
|March 13, 2024
概括
早期的侮辱可以通过氧化应激和肠道失调症来编程代谢综合征 (MetS). 针对肠道微生物群的干预措施有望防止 MetS 在以后的生活中发展.
科学领域:
- 发育生物学是发展生物学.
- 代谢障碍 代谢障碍 代谢障碍
- 微生物组研究的研究.
背景情况:
- 代谢综合征 (MetS) 是一组心血管疾病风险因素,起源于生命早期.
- 氧化应激和肠道失调是导致MetS病变的关键因素.
- 了解MetS的生命早期编程对于预防策略至关重要.
研究的目的:
- 检查 MetS 编程的生命早期的侮辱.
- 探索氧化应激和肠道微生物群在MetS启动中的作用.
- 审查针对肠道微生物群的干预措施,以防止MetS编程.
主要方法:
- 对MetS.中早期生活因素,氧化应激和肠道微生物群的现有文献的审查.
- 巩固对诸如益生菌,前生菌和后生菌等干预措施的证据.
- 对动物研究进行分析,并确定临床研究中的差距.
主要成果:
- 早期的侮辱可以启动MetS编程.
- 氧化应激和肠道失调是这种编程中的重要因素.
- 针对肠道微生物群的治疗在临床前模型中显示出潜力.
结论:
- 在生命早期针对氧化应激和肠道微生物群提供了一种对MetS的预防策略.
- 需要进行进一步的临床试验,以验证肠道微生物群调节对预防MetS的有效性.
- 干预措施包括益生菌,益生菌,后生菌和代谢物调节.
更多相关视频
09:31Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
Published on: September 17, 2021
4.0K
04:20Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model
Published on: July 12, 2024
1.6K
相关概念视频
Overview of Nitrogen Metabolism
Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of ammonia, ammonium ions, nitrate, nitrite, or nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this nitrogen...
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this nitrogen...
Oxygen Requirements and Growth Patterns
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
Probiotics
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Designing Growth Media for Bioreactors
Growth media provide essential nutrients that support cell growth and metabolism, thereby enhancing the yield of valuable products such as enzymes, antibiotics, and biomass. Designing an effective growth medium involves balancing all components to prevent nutrient limitations or toxic excesses, both of which can impair growth and reduce product yields.Composition of a Typical Growth MediumA typical growth medium contains carbon and nitrogen sources, salts, vitamins, trace elements, and...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
