在后代中过量服用母体叶酸补充剂的风险
Xiguang Xu1,2, Ziyu Zhang1,3, Yu Lin1,2,4
1Epigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Nutrients
|March 13, 2024
概括
母亲过度摄入叶酸 (FA) 可能会对后代的发育产生负面影响. 本综述考察了母体高FA对儿童和小鼠模型神经发育和基因表达的潜在不良影响.
科学领域:
- 营养科学 营养科学
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 叶酸 (维生素B9) 对细胞代谢和预防神经管缺陷至关重要.
- 叶酸 (FA) 是用于强化和补充的合成形式.
- 人们担心母亲过度摄入FA的潜在不良影响.
研究的目的:
- 审查最近关于母亲过量摄入FA对后代影响的研究结果.
- 综合人类临床试验和小鼠模型的数据.
- 为了突出有关母亲叶酸水平升高的担忧.
主要方法:
- 总结了人类临床试验数据关于周周受孕FA摄入量和后代神经发育.
- 从小鼠模型中汇编的关于高母性FA补充效果的发现.
- 审查了后代的分子水平和行为变化.
主要成果:
- 过度的母体FA摄入可能会对后代产生不良影响.
- 潜在的影响包括神经发育和基因表达的改变.
- 母乳叶酸水平升高是一个日益严重的公共卫生问题.
结论:
- 过度的母乳叶酸补充需要进一步调查.
- 了解这些风险对于公共卫生建议至关重要.
- 需要进一步的研究才能充分阐明对后代的影响.
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