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聚乳酸/β-三酸 (PLA/β-TCP) 复合材料在SBF中浸泡时的结构,热和形态特征:全面分析

Sondes Ftiti¹, Sandra C Cifuentes², Awatef Guidara¹

¹Laboratory of Advanced Materials (LR01ES26), National Engineering School of Sfax, University of Sfax, Sfax 3038, Tunisia.

|March 13, 2024

概括

这项研究研究了PLA/β-TCP生物复合物,揭示了β-酸 (β-TCP) 在模拟体液 (SBF) 中转化为碳酸酸. 这种转变影响了PLA的降解和结晶,这对医疗应用至关重要.

科学领域:

生物材料科学生物材料科学
聚合物科学聚合物科学
材料化学材料化学

背景情况:

聚乳酸 (PLA) 是一种可生物降解的聚合物,具有医学应用的潜力.
β-三酸 (β-TCP) 是一种生物陶,经常被纳入PLA以增强其性能.
了解PLA/β-TCP复合材料的降解行为对于其临床使用至关重要.

研究的目的:

在模拟体液 (SBF) 中浸泡后研究PLA/β-TCP生物复合物的生物活性,形态和热特性.
分析β-TCP的演变及其在降解过程中与PLA的相互作用.
为预测PLA/β-TCP在医疗应用中的性能提供有关PLA/β-TCP降解机制的见解.

主要方法:

制造具有不同β-TCP含量 (10-25%重量) 的PLA/β-TCP生物复合材料薄膜. 使用溶剂造.
复合材料在SBF中浸泡7,14和21天.
使用SEM,EDX,减肥,XRD,FTIR,DSC,TGA和GPC进行表征.

主要成果:

在SBF中浸泡后,β-TCP转化为碳酸酸,随着时间的推移转化增加.
酸和β-TCP之间的相互作用不同于酸和碳酸酸.
β-TCP抑制了PLA的水解,但加速了热降解,并阻碍了PLA的结晶性,尽管SBF浸泡后来促进了结晶.

结论:

β-TCP转化为碳酸酸的演变显著影响了PLA/β-TCP生物复合物的降解行为.
对PLA/β-TCP降解的准确分析需要考虑这种β-TCP转化.
这些发现提高了对PLA/β-TCP降解机制的理解,有助于对医疗应用的预测.

关键词:

结晶性结晶性是指结晶性.凝透色谱学凝透色谱学多乳酸多乳酸是什么意思溶剂造技术是一种溶剂造技术.酸-三酸 (β-tricalcium phosphate) 是一种酸盐.

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