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解码HiPSC-CM对SARS-CoV-2的反应:绘制心脏损伤的分子景观

Sicheng Chen1, Zhenquan Fu2, Kaitong Chen3

  • 1Department of Cardiology, Shantou Central Hospital, Shantou, 515031, China.

BMC genomics
|March 13, 2024
PubMed
概括

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 在人类诱导的多能干细胞衍生的心肌细胞 (hiPSC-CMs) 中的感染主要导致线粒体功能障碍. 针对这种功能障碍可能有助于治疗COVID-19相关的心脏并发症.

关键词:
生物学意义 生物学意义线粒体功能障碍 线粒体功能障碍分子机制的分子机制这就是SARS-CoV-2病毒.对转录组进行分析.这就是hiPSC-CMs.

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