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青春期和之后的乳房组成:智利生长和肥胖队列研究
Ana Pereira1, María Luisa Garmendia2, Valeria Leiva1,3
1Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Breast cancer research : BCR
|March 13, 2024
概括
青春期期间乳腺密度 (BD) 的发展是乳腺癌 (BC) 风险的关键. 高%的FGV和AFGV在青春期跟踪到成年期,BMI z-score和初潮以来的时间是关键决定因素.
科学领域:
- 生殖健康 生殖健康
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 乳腺密度 (BD) 是乳腺癌 (BC) 的重要危险因素.
- 了解青春期乳腺发育及其决定因素对于早期BC预防策略至关重要.
- 关于青春期乳腺密度轨迹的数据有限.
研究的目的:
- 在拉丁裔队列中,在乳房色阶段至经月经后4年内,对%纤维腺体体积 (%FGV),绝对纤维腺体体积 (AFGV) 和乳房体积 (BV) 的特征.
- 在青春期和成熟乳房中确定高%FGV和AFGV的决定因素.
主要方法:
- 对509名来自中低社会经济地位背景的女孩进行了纵向跟踪.
- 测量包括体重,身高,性成熟 (乳腺色阶段,初潮时的年龄) 和使用双能X射线吸收计 (DXA) 的BD.
- 数据从幼儿时期到经期4年后收集.
主要成果:
- 在坦纳阶段,FGV的百分比增加,在经期后250天左右达到顶峰.
- AFGV和BV在初潮后大约2年达到峰值.
- 在Tanner阶段B4/B5期间高%的FGV,AFGV和BV预测了经月经后更高的值.
- 体重指数z-score (44%) 和初潮后的时间 (42%) 分别是%FGV和AFGV变化的主要决定因素.
结论:
- 青春期乳腺发育代表了乳腺癌易感性的关键窗口.
- 早期青春期乳腺组成,特别是高%FGV和AFGV,持续到成年.
- 需要进一步的成年人随访,以将这些发育变化与BC风险联系起来.
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