抗发作药物可以改变叶的脑结构吗? 一个前性研究研究
Ilaria Sammarra1, Maria Eugenia Caligiuri2, Maria Celeste Bonacci3
1Department of Medical and Surgical Sciences, Institute of Neurology, Magna Græcia University of Catanzaro, Catanzaro, Italy.
Epilepsia open
|March 13, 2024
概括
抗发作药物 (ASM) 在轻度间叶 (MTLE) 患者中没有显著改变大脑结构. 然而,在接受治疗和未接受治疗的MTLE个体中,与健康对照人群相比,皮质皮质变薄.
科学领域:
- 神经成像是一种神经成像.
- 发病学 (Epileptology) 是一个专业的学科.
- 神经学 神经学
背景情况:
- 轻度叶 (MTLE) 患者可能未接受治疗或接受单次抗发作药物治疗.
- 这一患者群是研究ASM对大脑结构的影响的理想选择.
- 以前的研究表明本身可以引起大脑结构的变化.
研究的目的:
- 研究ASM对轻度MTLE患者大脑结构的影响.
- 为了比较未经治疗的MTLE患者,ASM治疗的MTLE患者和健康对照者之间的大脑形态.
主要方法:
- 56名轻度MTLE患者 (22人未接受治疗,34人接受单疗法) 和58名健康对照患者接受了3T大脑MRI.
- 使用FreeSurfer进行了自动形态测量.
- 使用ANCOVA分析灰质差异,根据年龄,疾病持续时间和内体积进行调整.
主要成果:
- 在治疗和未治疗的MTLE患者之间没有发现显著的灰质差异.
- 与对照组相比,单疗法患者在特定的左侧和右侧部和部区域显示皮质厚度降低.
- 与对照人群相比,未经治疗的MTLE受试者在带状回形的左侧峡谷中表现出灰色物质增加.
结论:
- 在未治疗和单疗轻度MTLE患者之间没有观察到实质性的形态差异.
- 这些发现表明ASM在这种轻度的MTLE人群中影响神经成像结果方面发挥的作用很小.
- ,独立于治疗,与特定大脑区域的皮质稀释有关.
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