根据分析,SNHG5表达的增加与癌症预后不佳有关
Qiang Huang1, Yi-Gui Xia1, Yong-Jian Huang1
1Department of Laboratory Medicine, Hechi Hospital Affiliated to Youjiang Medical University for Nationalities, the People's Hospital of Hechi, Hechi, 547000, Guangxi, China.
European journal of medical research
|March 13, 2024
概括
瘤中小核宿主RNA 5 (SNHG5) 表达率升高与癌症预后不佳相关. 这种长长的非编码RNA显示出作为各种癌症的治疗标和预后生物标记物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 小核宿主RNA 5 (SNHG5) 是一个长的非编码RNA,在各种癌症中经常过度表达.
- 增加SNHG5表达与癌症患者的生存结果较差有关.
研究的目的:
- 进行元分析,评估SNHG5表达与癌症患者的临床结果之间的相关性.
- 评估SNHG5作为潜在的预后生物标志物和治疗点.
主要方法:
- 在六个电子数据库中进行了系统的文献搜索.
- 在应用预先定义的标准后,包括了11项涉及721名患者的研究.
- 纽卡斯尔-太华尺度被用于质量评估;危险比率和赔率比率被组合用于分析.
主要成果:
- 高SNHG5表达与晚期TNM阶段和较大的瘤大小有关.
- 虽然观察到不良预后的趋势 (HR=1.90),但它没有达到统计学意义.
- 在SNHG5表达和远程转移,淋巴结转移,组织学等级,侵袭深度,年龄或性别之间没有发现显著的相关性.
结论:
- 在大多数瘤组织中,SNHG5的升高调节可能表明癌症患者的预后不佳.
- SNHG5代表了一个有前途的潜在治疗标和癌症可靠的预后生物标志物.
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