血sCD146是慢性阻塞性肺病急性恶化的潜在生物标志物
Xinyu Jia1, Jingxian Jiang1, Chen Yang2
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Clinical and translational science
|March 13, 2024
概括
在经历慢性阻塞性肺病 (COPD) 急性恶化患者中,可溶性CD146 (sCD146) 水平较低. 下SCD146与疾病严重程度的增加有关,并作为COPD恶化的一个独立风险因素.
科学领域:
- 肺部医学 肺部医学
- 生物标志物 生物标志物
- 免疫学 免疫学 免疫学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个重大的全球健康挑战.
- 确定COPD恶化的可靠生物标志物对于及时干预至关重要.
- 溶性CD146 (sCD146) 是一种细胞粘附分子,在炎症性疾病中具有潜在的作用.
研究的目的:
- 为了研究COPD患者的血sCD146水平.
- 评估sCD146水平与COPD严重程度之间的相关性.
- 确定sCD146是否可以作为COPD急性恶化 (AECOPD) 的生物标志物.
主要方法:
- 从97名COPD患者 (13名稳定,84名恶化) 收集了血样本.
- 测量了sCD146水平,并在稳定和恶化的组之间进行了比较.
- 分析了与COPD严重性指数 (mMRC,GOLD阶段,CAT得分,住院病例) 的相关性.
- 进行了后勤回归和ROC分析,以评估sCD146作为AECOPD的生物标志物.
主要成果:
- 与稳定患者相比,COPD恶化患者的sCD146血水平显著降低.
- 较低的sCD146水平与较高的COPD严重程度相关 (较高的mMRC,GOLD阶段4,更多的住院治疗,较高的CAT得分).
- sCD146被确定为AECOPD的独立风险因素.
- sCD146,结合临床因素,在识别AECOPD时表现出高准确度 (AUC=0.908).
- 血sCD146与S100A9水平呈负相关性.
结论:
- 在COPD恶化期间,sCD146的血水平下降.
- sCD146可以作为一个有价值的生物标志物来评估COPD严重程度和预测AECOPD.
- 进一步研究sCD146在COPD病原发生中的作用是有必要的.
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