性别特定的分布式白物质在患有焦虑症的青春期前青少年中的微架构变化:一项大型分析研究
Nakul Aggarwal1, Do P M Tromp1, Jennifer U Blackford1
1Department of Psychiatry, University of Wisconsin-Madison (Aggarwal, Tromp, Roseboom, Williams, Kalin); Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha (Blackford); Section on Developmental and Affective Neuroscience, NIMH, Bethesda, Md. (Pine).
The American journal of psychiatry
|March 13, 2024
概括
儿童焦虑障碍显示出性别特异的白质变化 (WM). 与女孩不同的是,患有焦虑症的男孩减少了未切割的囊 (UF) 完整性和广泛的WM改变,这表明潜在的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 儿童精神病学 儿童精神病学
- 发展心理学 发展心理学
背景情况:
- 焦虑症在儿童中很常见,在关键白质 (WM) 发育时期出现.
- 之前的研究表明,在患有焦虑症的男孩中,未切割的囊 (UF) 中,WM微结构完整性 (微分异构 [FA]) 的性别特异性降低.
- 了解这些WM变化对于解决儿童焦虑至关重要.
研究的目的:
- 在青春期前的儿童中,与焦虑症和性相关的WM改变的特征.
- 证实和扩展以前关于儿童焦虑中性别特异性WM变化的发现.
- 调查迄今为止最大的青春期前儿童样本,以检查与焦虑症相关的WM变化.
主要方法:
- 一个大型分析,将现有的扩散张力成像数据与一个新的数据集结合起来.
- 包括165名患有焦虑障碍的儿童和132名健康志愿者 (8-12岁).
- 分析包括WM完整性的通道图和语音智能评估,检查群体差异,性别影响和相互作用.
主要成果:
- 在患有焦虑症的男孩中,未切割的囊 (UF) 分数异质 (FA) 显著减少,但在女孩中没有.
- 确定了广泛的,与焦虑症相关的WM变化,特别是在不同大脑区域的男孩身上.
- 证明焦虑障碍与男孩的WM变化广泛分布,而不是女孩的WM变化有关.
结论:
- 青春期前男孩的焦虑障碍,但不是女孩,与UFFA的显著减少和广泛的WM改变有关.
- 这些发现强调了性对理解儿童焦虑的神经生物学基础的重要性.
- 微观结构的改变可能成为儿童焦虑症治疗的潜在新治疗标,特别是在男孩中.
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