在三个澳大利亚社区中,暴露于基和多基物质的儿童发育弱点的相对风险:数据链接研究研究
Hsei Di Law1, Bruce K Armstrong2, Catherine D'este1
1National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT 2601, Australia.
International journal of population data science
|March 13, 2024
概括
这项研究发现,在澳大利亚住宅区暴露在和多基物质 (PFAS) 的儿童中,发育风险增加的证据不足. 需要进一步的研究,才能充分了解PFAS暴露对儿童发育的潜在长期影响.
科学领域:
- 环境健康 环境健康
- 儿科流行病学 儿科流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 含有per-和多基物质 (PFAS) 的水性薄膜形成泡 (AFFF) 已经污染了澳大利亚Katherine (NT),Oakey (Qld) 和Williamtown (NSW) 的住宅区.
- 对于PFAS暴露对这些受影响社区儿童发育的潜在影响存在担忧.
研究的目的:
- 调查居住在澳大利亚PFAS污染地区的儿童是否与未被污染的比较区域的儿童相比,具有更高的发育脆弱性风险.
- 在多个领域评估住宅PFAS暴露与儿童发育结果之间的关联.
主要方法:
- 利用2009-2018年澳大利亚早期发育人口普查 (AEDC) 数据,将暴露和比较区域的儿童与医疗保险入学档案数据联系起来.
- 估计的相对风险 (RRs) 的发展脆弱性在五个AEDC领域和总结措施,调整社会人口统计学因素和混因素.
- 包括大量的儿童队列:来自NT的2,429名,来自Qld的2,592名和来自新南威尔士的510名.
主要成果:
- 凯瑟琳在沟通技巧和一般知识方面的发育脆弱性风险较低 (RR=0.74,95% CI 0.57-0.97).
- 在Oakey中,在沟通技巧/一般知识 (RR=1.49,95% CI 1.18-1.87) 和身体健康/福祉 (RR=1.31,95% CI 1.06-1.61) 方面发现了发育脆弱性的更高风险.
- 对于其他领域或领域,没有发现显著差异或不确定的风险,通常是由于事件数量较小.
结论:
- 目前,缺乏充分的证据表明,生活在澳大利亚这三个受PFAS影响地区的儿童的发育脆弱性风险增加.
- 虽然在Oakey中发现了一些特定领域的风险,但总体发现表明,研究人员对PFAS暴露在研究群体中的广泛发育损害的确证据有限.
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