超快速的铁聚糖注入剂对于治疗铁缺乏症是安全的
Iouri Banakh1, Martha Turek2, Daniel Niewodowski3
1Emergency Department Pharmacy Team leader, Pharmacy Department, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia.
GE Portuguese journal of gastroenterology
|March 13, 2024
概括
超快速的铁聚糖注射是安全的,并被患者接受,为铁缺乏症的慢速治疗提供了一个方便的替代方案. 这种方法的安全性与铁性碳酸相提并论,有可能降低医疗保健成本.
科学领域:
- 内部医学 内部医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 缺铁很普遍,特别是在患有慢性疾病的患者中,如功能衰竭,心力衰竭和炎症性肠道疾病.
- 静脉注射铁是标准的治疗方法,但目前的方法涉及长时间的输液或多剂量.
研究的目的:
- 为了评估超快速铁聚糖输注的安全性和患者接受度.
- 为了比较超快速输注与较慢的铁聚马尔托斯和铁炭马尔托斯的输注.
主要方法:
- 这是一项开放式的第四阶段安全性研究,涉及300名参与者,在15分钟内接受高达1500毫克的铁聚糖.
- 与1小时和4小时输注的历史对照对比急性不良事件 (AE) 率和严重程度的比较.
- 评估延迟的副作用和参与者对未来输液的偏好.
主要成果:
- 急性AE率为18.7%,严重AE率为1.0%.
- 轻度AE的发病率在超快速输注中高于较慢输注 (p < 0.001),但中度和严重AE的发病率相似.
- 延迟反应发生在12.5%的参与者中,超过95%的人更喜欢重复的超快速输注.
结论:
- 超快速的铁聚糖注射是治疗缺铁的安全和有效方法.
- 这种方法的安全性与铁性碳酸相似,提高了患者的便利性,同时可能降低医疗保健费用.
相关概念视频
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
153
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
153
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
129
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
129
Renal Failure: Dose Adjustments
88
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
88
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Enteral Nutrition I: Orogastric and Nasogastric Feeding
276
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
276
Routes of Drug Administration: Parenteral
1.9K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.9K


