原蛋白:在睡眠和衰老的交叉点上的自然分子
Daniel J Kramer1, Adiv A Johnson1
1Tally Health, New York, NY, United States.
Frontiers in nutrition
|March 13, 2024
概括
原蛋白是一种天然的黄类化合物,可以提高NAD+水平,并且在各种动物模型中显示出改善睡眠和寿命的前景. 人类研究表明,阿比基尼尼.
科学领域:
- 生物化学和衰老研究研究.
- 神经科学和睡眠研究研究
- 自然产品化学 自然产品化学
背景情况:
- 尼古丁胺胺氨基二核酸 (NAD+) 对新陈代谢至关重要,并且随着年龄的增长而下降.
- 在香中发现的一种黄胺 (apigenin) 抑制了CD38,这是消耗NAD+的酶.
- 与年龄相关的NAD+下降与各种健康问题有关,包括睡眠障碍和寿命减少.
研究的目的:
- 研究原蛋白对NAD+水平,睡眠和寿命的影响.
- 根据其分子结构和生物活动来探索apigenin的治疗潜力.
- 综合来自动物模型和人类研究的证据,以了解原蛋白的益处.
主要方法:
- 在小鼠模型中服用阿皮基宁以评估NAD+水平和认知功能.
- 对原蛋白对和虫的生存和疾病模型的影响的评估.
- 对香提取物的人类临床研究和对饮食中的阿皮根因摄入量的流行病学数据的综述.
主要成果:
- 在小鼠中,阿皮基宁治疗提高了NAD+水平.
- 原蛋白改善了小鼠的学习,记忆,并减少了瘤的扩散.
- 原素在和虫中延长了寿命,并表现出镇静作用.
- 人类研究将香提取物与减少焦虑和改善情绪联系起来;饮食中的原蛋白与更好的睡眠质量相关.
结论:
- 原蛋白在调节衰老过程和改善睡眠质量方面显示出显著的潜力.
- 它抑制CD38和与各种分子标相互作用的能力凸显了它的治疗多功能性.
- 需要进一步的研究来阐明apigenin的机制和临床应用.
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