腹部海马体被激活在嗅觉,但不是听觉的威胁记忆
Tayebeh Sepahvand1, Samantha J Carew1, Qi Yuan1
1Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada.
Frontiers in neural circuits
|March 13, 2024
概括
背部海马体有助于与上下文相关的威胁记忆,而腹部海马体对于嗅觉威胁记忆至关重要,无论上下文如何.
科学领域:
- 神经科学是一个神经科学.
- 记忆研究 记忆研究
- 行为科学 行为科学
背景情况:
- 对于记忆至关重要的海马体有明显的背部和腹部区域.
- 背部海马与上下文有关,腹部与关联性调节中的情绪有关.
- 在威胁条件化中理解感官模式的作用仍然不完整.
研究的目的:
- 研究背部和腹部海马在嗅觉与听觉威胁调节中的不同作用.
- 为了确定上下文相关性如何影响背部海马激活在威胁记忆回忆期间.
- 阐明腹部海马对嗅觉威胁记忆的特定贡献.
主要方法:
- 在嗅觉和听觉威胁调节回忆过程中比较背部和腹部海马体激活.
- 评估一夜间环境习惯对海马激活的影响.
- 分析与腹部海马活动相关的同时发生的状皮质激活.
主要成果:
- 在嗅觉威胁记忆回忆过程中背部海马体的激活取决于情境暗示的相关性.
- 背部海马激活被上下文习惯性取消,这表明它不支持依赖暗示的条件.
- 室内海马体在嗅觉威胁记忆回忆中激活,不管习惯性,但听觉威胁记忆并非如此.
- 皮质皮质的激活与嗅觉威胁记忆回忆期间的腹部海马体活动相关.
结论:
- 背部海马体编码了嗅觉威胁记忆的上下文方面.
- 腹部海马在嗅觉威胁调节中发挥着特定的作用,可能是通过皮质皮层连接.
- 感官模式显著影响海马体亚区域参与威胁记忆.
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