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全国Etoricoxib注射临床经验 (NICE):印度患者的真实世界证据
Umesh Shetty1, Pramod Neema2, S Muthu3
1Orthopaedics, Axis Multispecialty Hospital, Mumbai, IND.
Cureus
|March 13, 2024
概括
肌肉内注射埃托里科克西布在印度有效管理急性疼痛,显著减少疼痛和高耐受性. 这种新的配方为疼痛管理提供了一个有希望的替代方案.
科学领域:
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 疼痛是一个全球性的健康问题,口服埃托里科克西布 (选择性COX-2抑制剂) 已被确立为止痛.
- 有限的研究存在于埃托里科克西布的替代注射途径,如肌内注射 (IM).
研究的目的:
- 为了评估一种新的90 mg/mL IM etoricoxib注射配方的有效性和安全性.
- 评估IM etoricoxib在印度门诊环境中治疗急性疼痛的疗效.
主要方法:
- 一项现实世界,多中心,回顾性,观察性研究,涉及印度42个中心的383名患者.
- 收集的数据患者人口统计学,临床变量,并发症和疼痛评分 (视觉模拟量表 - VAS) 之前和之后的IM etoricoxib管理.
- 在注射后30分钟和60分钟分析了安全性和有效性.
主要成果:
- 从基线到30分钟和60分钟的VAS得分显著降低 (p < 0.0001).
- 严重疼痛从基线时的98.17%降低到30分钟后的6.78%和60分钟后的4.17%.
- 耐受性高,98.69%的患者没有报告任何不良事件; 70.23%的医生更喜欢它而不是其他NSAID注射.
结论:
- 在印度,90 mg/mL IM etoricoxib注射证明了急性疼痛管理的有效性和良好的耐受性.
- 这种新的配方为急性疼痛提供了一个有前途的治疗选择,为患者提供了显著的益处.
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