抗生素消费与耐药性之间的关系:系统性审查
Asrat Agalu Abejew1,2, Gizachew Yismaw Wubetu3, Teferi Gedif Fenta1
1Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
概括
抗生素耐药性 (ABR) 与抗生素消费 (ABC) 有正相关. 减少不必要的抗生素使用和优化治疗对于防止ABR传播至关重要.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 没有保留的抗生素使用驱动了耐药细菌菌株的选择.
- 抗生素耐药性 (ABR) 和抗生素消耗 (ABC) 之间的联系需要进一步研究.
- 本综述侧重于2016年至2022年ABC和ABR之间的关系.
研究的目的:
- 系统地审查抗生素消费与抗生素耐药性之间的关系.
- 分析2016年至2022年间发表的研究数据.
主要方法:
- 从2022年12月23日至31日进行了系统的文献搜索.
- 使用了与抗生素消费和抗生素耐药性相关的关键词.
- 在最初的3367件作品中,选出了58件符合条件的作品.
主要成果:
- 综合抗生素消费量很大,超过70%来自世卫组织观察和储备类别.
- 抗生素耐药性的平均综合流行率为38.4%.
- 在81%的研究中观察到抗生素消费和抗生素耐药性之间的正相关性,在*P. aeruginosa*,*E. coli*和*K. pneumoniae*中发现了特定的相关性.
结论:
- 抗生素消费和抗生素耐药率之间存在显著的正相关性.
- 确定了不同类别的抗生素和ABR之间的交叉耐药性.
- 优化抗生素治疗和实施管理计划对于制ABR的出现和传播至关重要.
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