小反动物瘟疫病毒遗传系的比较进化分析
Maxime Courcelle1,2, Habib Salami1,2,3, Kadidia Tounkara1,2,4
1ASTRE, University of Montpellier, CIRAD, INRAE, Montpellier F-34398, France.
Virus evolution
|March 13, 2024
概括
小动物瘟疫病毒 (PPRV) 基因组测序揭示了复杂的进化历史和II系和IV系之间的不同选择压力. 增加测序工作对于PPRV根除策略至关重要.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 进化生物学 进化生物学
背景情况:
- 小动物瘟疫病毒 (PPRV) 造成重大经济损失,并影响全球的粮食安全.
- 全基因组测序对于了解PPRV流行病学和根除至关重要,但目前的数据有限且有偏见.
- 遗传系IV (LIV) 代表过多,而其他系,如系II (LII) 的研究较少.
研究的目的:
- 为了比较PPRV Lineage II (LII) 和 Lineage IV (LIV) 的进化压力和历史.
- 分析历史和最近的PPRV样本,专注于西非的LII.
- 提供对PPRV多元化,扩散和控制战略的洞察力.
主要方法:
- 为25个近期和7个历史的PPRV样本生成基因组序列.
- 进行了基因组学分析,以了解进化关系.
- 进行了分子进化分析,包括编码子的使用和选择压力.
主要成果:
- 遗传学分析揭示了西非复杂的LII循环,并建议LIV的非洲起源.
- 现代LII和LIV菌株的分歧估计在20世纪60年代至80年代,这是PPRV传播的关键时期.
- 在LII和LIV菌株之间观察到密码体使用和适应性选择压力的显著差异.
结论:
- 对比基因组分析为PPRV进化历史和流行病学提供了宝贵的见解.
- 不同的血统 (LII和LIV) 在不同的选择压力下演变.
- 加快PPRV基因组测序对于有效的控制和监测策略至关重要.
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