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Updated: Jul 1, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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通过DNA和RNA点激活CRISPR Cas12a核酶的决定因素

Eric A Nalefski1, Remy M Kooistra1, Ishira Parikh1

  • 1Global Health Labs, Inc, Bellevue, WA 98007, USA.

Nucleic acids research
|March 13, 2024
PubMed
概括

CRISPR-Cas12a酶激活涉及两个步骤,目标DNA序列和结构显著影响其核酶活性. 这项研究澄清了Cas12a在细菌免疫和诊断应用中的功能.

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