在儿童中测量阿拉宁氨基转移酶的实践:增加值的时间变化和病因学
Linnea Aitokari1,2,3, Pauliina Hiltunen4, Heini Huhtala5
1Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Journal of pediatric gastroenterology and nutrition
|March 13, 2024
概括
在儿童中,氨酸胺转移酶 (ALT) 测试显著增加,但ALT水平的升高保持稳定. 这表明,增加ALT测量通常是合理的,尽管测试效率因部门而异.
科学领域:
- 儿科医学 儿科医学
- 临床化学 临床化学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 关于儿童的氨酸氨基转移酶 (ALT) 测量实践的数据有限.
- 了解与ALT升高相关的诊断对于临床管理至关重要.
研究的目的:
- 评估儿科患者ALT测量实践中的趋势.
- 确定儿童ALT升高的常见急性和慢性原因.
- 评估增加ALT测试的合理性和效率.
主要方法:
- 在1992年至2018年期间,对来自28,118名儿童 (1至16岁) 的145,092个ALT测量进行了回顾性分析.
- 从2008-2018年收集的诊断数据.
- 分析测试频率,ALT升高的患病率和相关诊断.
主要成果:
- ALT检测增加了3.9倍 (21至81/1000名儿童),ALT患病率升高稳定 (18-26%).
- 在急诊,风湿病学,胃肠病学,血液瘤学和精神病学中观察到更多的测试.
- 常见的急性原因:感染 (45%),血液瘤 (17%). 慢性原因:自身免疫性疾病 (28%),精神疾病 (14%),以及与代谢功能障碍相关的脂肪性肝病 (10%).
结论:
- 儿童ALT检测的增加似乎可以通过稳定的ALT比例的升高来证明.
- 各部门的测试效率各不相同,这表明有优化潜力.
- 对特定部门测试协议的进一步研究可能会提高ALT测量效用.
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