在患有勒维体痴呆症的长度自由水变化
Shannon Y Chiu1,2, Robin Chen3, Wei-En Wang3
1Department of Neurology, University of Florida, Gainesville, Florida, USA.
概括
随着时间的推移,自由水 (FW) 成像显示了Lewy体 (DLB) 痴呆症中神经退行症的增加. 这些微观结构变化与认知和运动衰退相关,支持dMRI作为追踪DLB进展的工具.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 生物标志物 生物标志物
背景情况:
- 扩散权重磁共振成像 (dMRI) 在体内评估组织微观结构.
- 之前的dMRI研究在痴呆症与勒维体 (DLB) 已经显示了不一致的结果.
研究的目的:
- 使用自由水 (FW) 成像来评估DLB的进展.
- 为了将FW变化与DLB患者的临床衰退相关联.
主要方法:
- 基线和随访MRI在12个月和24个月获得了27名患有DLB或轻度认知障碍与勒维体 (MCI-LB) 的个人.
- 免费水 (FW) 使用梅奥诊所成人寿命模板进行了分析.
- 来自阿尔茨海默病神经影像计划的20名认知正常的个体被纳入了纵向比较.
主要成果:
- 与基线相比,12个月和24个月后,在多个大脑区域 (包括胰岛,杏仁体和带状皮质) 观察到显著的FW增加.
- 在24个月后,观察到更广泛的微观结构变化,特别是在与视觉空间处理,运动和胆固醇功能相关的区域.
- 肌肉运动变化与认知 (蒙特利尔认知评估 - MoCA) 和运动 (运动障碍学会-统一帕金森病评分表 - MDS-UPDRS) 评分的纵向恶化有显著的相关性.
结论:
- 在灰色和白质区域积累的自由水 (FW) 表明DLB的神经退行性病理和疾病进展.
- 观察到的FW变化与临床衰退之间的关联凸显了其作为DLB进展标志物的潜力.
- dMRI,特别是FW成像,显示出作为监测DLB疾病进展的工具的希望.
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