可注射的水凝输送系统具有高药物负载,用于延长局部麻醉
Yongchun Li1, You Chen2, Yifan Xue2
1Department of Anesthesiology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, Guangdong, 510060, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 13, 2024
概括
这项研究开发了一种新的可注射水凝系统,用于长期的术后疼痛缓解. 该系统有效地提供两种麻醉剂,ropivacaine和dexmedetomidine,提供延长疼痛控制与减少阿片类药物的使用.
科学领域:
- 生物材料科学 生物材料科学
- 麻醉学 麻醉学
- 药物输送系统 药物输送系统
背景情况:
- 外围神经阻塞提供精确的疼痛控制,副作用比系统性阿片类药物手术后更少.
- 可注射的水凝由于其生物相容性和水合性,因此对局部麻醉药物提供有希望.
- 实现高药载荷和持续释放水溶性麻醉剂仍然是一个重大挑战.
研究的目的:
- 设计一个两步注射复合药物输送系统,用于长期局部麻醉.
- 为了实现高药物负载和可控释放的罗皮瓦卡因和德克斯梅德托米丁.
- 评估开发的长期术后疼痛管理系统的体内疗效.
主要方法:
- 使用微流体制备载有罗皮瓦卡因 (HMS-ROP) 的异质水凝微球.
- 制造一种可注射的自愈水凝基质 (Gel) 基质,由改性碳素甲基纤维素和氧化氨酸制成.
- 开发一种复合系统 (Gel/HMS-ROP/dexmedetomidine),用于持续释放药物.
主要成果:
- HMS-ROP实现了41.1%的药物加载,而体外释放时间超过160小时.
- 在体内,复合系统的感觉和运动阻塞持续时间分别为48小时和36小时.
- 观察到顺序释放和协同镇痛效应.
结论:
- 开发的可注射水凝系统可实现高药载荷和局部麻醉剂的长期控制释放.
- 该系统通过连续释放和协同效应提供了长期的术后疼痛管理.
- 这一策略为手术后有效的,长效的疼痛控制提供了一个有希望的方法.
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