纳米颗粒协同铁和cuproptosis来增强癌症免疫治疗的潜力
Youyou Li1, Jing Liu1,2, Yimei Chen1
1Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 13, 2024
概括
研究人员开发了一种提供铜和埃拉斯的纳米粒子,以诱导癌症细胞死亡. 这种组合疗法增强了免疫反应,并且在治疗结肠癌和乳腺癌方面表现有前途.
科学领域:
- 生物医学工程 生物医学工程
- 癌症治疗 癌症治疗
- 纳米医学是一种纳米医学.
背景情况:
- 细胞亡,一种新的细胞死亡途径,是癌症治疗的有希望的目标.
- 埃拉斯诱导铁,提供与cuproptosis潜在的协同效应.
研究的目的:
- 设计和评估一个核心外纳米粒子 (CuP/Er),用于共同提供铜 (Cu) 和埃拉斯 (Er).
- 为了研究由CuP/Er诱导的cuproptosis和ferroptosis在癌细胞中的协同效应.
- 评估CuP/Er在癌症治疗中与免疫疗法结合使用的潜力.
主要方法:
- 合成和表征CuP/Er核心外纳米粒子.
- 在体外评估CuP/Er诱导的细胞死亡,线粒体损伤和免疫反应.
- 使用大肠腺癌和三阴性乳腺癌的小鼠模型的体内研究.
主要成果:
- CuP/Er纳米颗粒有效地联合输送铜和埃拉斯,诱导协同性的铜和铁.
- 埃拉斯通过耗尽谷氨和增加脂质过氧化,使癌细胞对铜诱导的质变敏感.
- CuP/Er治疗促进了免疫细胞死亡,增强了抗原呈现,并上调了PD-L1表达.
- 使用CuP/Er和免疫检查点阻塞的联合治疗导致瘤回归,并在临床前模型中预防转移.
结论:
- CuP/Er纳米颗粒提供了一种新的策略,用于共同输送铜和埃拉斯,以诱导协同作用的细胞死亡.
- 杯和铁的结合增强了抗瘤免疫反应.
- 这种基于纳米粒子的方法具有显著的潜力,可以增强当前的癌症免疫疗法.
更多相关视频
04:01Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
962
08:02Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
Published on: May 14, 2021
5.6K
相关概念视频
01:27Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:15Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K