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Updated: Jul 1, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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最大化水性药物封装:小纳米颗粒的形成由葡萄糖和氨酸结合的甘油聚合物实现

Linqing Tian, Cheng Cao, Junming Ho

    Journal of the American Chemical Society
    |March 13, 2024
    PubMed
    概括

    这项研究引入了一种无有机溶剂的方法,使用葡萄糖和氨酸聚合物制造难溶性药物的纳米粒子. 这种方法提高了药物的溶解性和生物可用性,简化了纳米药物的开发.

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    Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles10:12

    Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

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    Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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