医学大麻使用在瘤学和相关结果:一个范围审查
Ana Carolina Valente1, Luis Phillipe Nagem Lopes2, Maria Eline Matheus3
1Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
概括
基于大麻的药物显示出治疗疼痛和恶心等癌症症状的潜力. 需要进一步的研究来证实它们在癌症患者中的长期安全性和有效性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 基于证据的医学 基于证据的医学
背景情况:
- 全球范围内,大麻素越来越多地用于癌症患者的症状管理.
- 本范围审查审查审查了大麻制药在瘤学中的治疗益处和不良影响.
研究的目的:
- 在癌症患者中绘制大麻素的治疗益处.
- 确定与使用大麻制药在瘤学中的不良影响.
主要方法:
- 根据乔安娜·布里格斯研究所的指导方针进行了全面的范围审查.
- 在多个数据库中进行广泛的文献搜索,包括PubMed,Embase和Google Scholar.
- 包括初级研究 (观察和随机) 评估大麻素在癌症患者中的有效性和安全性.
主要成果:
- 该审查包括35项研究,82.86%是随机对照试验.
- 四大麻素 (THC) 是最常被引用的大麻素,用于各种剂量和施用途径.
- 评估的主要结局是恶心和吐 (77.14%),食欲 (11.43%),疼痛 (8.57%) 和瘤回归 (2.86%).
结论:
- 大麻素在治疗与癌症相关的疼痛,吐和厌食症/尾症方面表现有前途.
- 进一步的大规模随机临床试验和长期安全性研究是必不可少的.
- 确认对抗常规治疗的癌症患者的药用实用性是未来的一个关键方向.
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