新生儿血清的参考值应在维生素D充足的人群中确定
Lucie Levaillant1,2, Agnès Linglart1,3, Vincent Gajdos4,5
1Centre de référence des maladies rares du métabolisme du calcium et du phosphate, AP-HP, Hôpital Bicêtre Paris-Saclay, service d'endocrinologie et diabète de l'enfant, filière OSCAR, DMU 3 SEA, 94270 Le Kremlin-Bicêtre, France.
The Journal of clinical endocrinology and metabolism
|March 13, 2024
概括
新生儿维生素D水平较高与血清的正常范围较高相关. 这表明,应根据维生素D状态调整新生儿血清的标准参考范围.
科学领域:
- 新生儿医学 新生儿医学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 新生儿的血清水平经常受到监测.
- 维生素D状态是影响新生儿血清的已知因素.
研究的目的:
- 调查25-氧维生素D (25OHD) 度是否影响新生儿正常血清范围的下限.
- 根据维生素D水平,建立一个更准确的新生儿血清的参考范围.
主要方法:
- 对1002对母婴新生儿进行了前性队列研究.
- 血清的测量是在生命的3天.
- 血清的参考范围是根据不同的25OHD度 (≥30nmol/L和≥50nmol/L) 建立的.
主要成果:
- 95%血清范围的下限在25OHD≥30nmol/L (P<0.05) 和≥50nmol/L (P<.001) 的新生儿中显著更高.
- 平均血清总水平显示趋向于更高的值,25OHD度增加.
结论:
- 与一般人群相比,新生儿的正常血清的下限在25OHD水平较高的新生儿中升高.
- 新生儿血清的建议参考范围为2.25至2.75mmol/L.
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