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循环中高水平的calprotectin与COVID-19患者的严重程度和高死亡率相关

Haoran Zhang¹, Qingyu Zhang¹, Kun Liu²

¹Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China.

Immunity, inflammation and disease

|March 13, 2024

概括

在严重的COVID-19病例中,calprotectin (S100A8 / S100A9) 的水平升高. 这一元分析表明,calprotectin是区分COVID-19严重程度和预测患者预后的有用生物标志物.

科学领域:

免疫学免疫学免疫学
生物标志物生物标志物
传染性疾病传染性疾病

背景情况:

冠状病毒疾病-2019 (COVID-19) 与高炎症有关.
免疫细胞分泌的蛋白质calprotectin (S100A8 / S100A9) 已与COVID-19的严重程度和预后有关.

研究的目的:

为了评估calprotectin在COVID-19患者的诊断和预后效用.
分析有关calprotectin在COVID-19中的作用的现有研究.

主要方法:

在PubMed,Web of Science和Cochrane图书馆进行了全面的文献搜索,截至2023年8月1日.
来自15项研究的数据使用Stata 16.0进行了元分析,以评估calprotectin水平和诊断疗效.

主要成果:

在严重的COVID-19患者中观察到高循环calprotectin水平 (SMD: 1.84).
卡尔普罗铁在严重的COVID-19中表现出高的诊断性能 (灵敏度:0.75,特异性:0.88,AUC:0.89).
较高的calprotectin水平与COVID-19患者的死亡风险增加有显著的相关性 (OR:8.60).

结论:

在严重的COVID-19中,calprotectin显著升高.
这种蛋白质可以作为评估COVID-19严重程度的有价值的生物标志物.
卡尔蛋白蛋白显示出预测COVID-19患者的预后的潜力.

关键词:

在 COVID-19 疫情中,生物标志物生物标志物这是一种calprotectin.这是一个元分析.系统性审查系统性审查

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