低剂量吗啡在慢性阻塞性肺病中不会引起嗜睡:一项随机临床试验的二次分析
Thomas J Altree1, Barbara Toson1, Kelly A Loffler1
1Flinders Health and Medical Research Institute-Adelaide Institute for Sleep Health, Flinders University, Bedford Park, South Australia, Australia.
低剂量持续释放吗啡在慢性阻塞性肺病 (COPD) 患者中不会加剧白天的嗜睡. 使用吗啡改善呼吸困难也可能提高睡眠质量和白天功能.
科学领域:
- 肺部医学 肺部医学
- 药理学 药理学是指药理学的学科.
- 睡眠医学 睡眠医学
背景情况:
- 慢性阻塞性肺部疾病 (COPD) 的持续性呼吸困难通常用低剂量持续释放的吗啡治疗.
- 这种治疗对患者的嗜睡,睡眠质量和日常功能的影响需要彻底调查.
研究的目的:
- 评估定期,低剂量,持续释放的吗啡对COPD患者睡眠参数的影响.
- 为了确定吗啡是否影响白天的嗜睡,感知睡眠质量和白天的功能.
主要方法:
- 来自一项为期4周的随机试验的睡眠问卷数据的二次分析,将持续释放吗啡与安慰剂进行比较.
- 参与者接受了蒙蔽的吗啡 (8-32毫克/天).
- 验证的问卷包括爱普沃思睡眠度量 (ESS),卡罗林斯卡睡眠度量 (KSS) 和利兹睡眠评估问卷 (LSEQ).
主要成果:
- 在吗啡组和安慰剂组之间没有观察到第1周睡眠分数 (ESS,KSS) 的显著差异.
- 这些对嗜睡的中性影响在整个4周的研究期间持续存在.
- 参与者报告说,用吗啡减少了呼吸困难,在LSEQ领域也有所改善,包括睡眠质量和白天功能.
结论:
- 定期,低剂量,持续释放的吗啡不会对经历呼吸困难的COPD患者的白天嗜睡产生不利影响.
- 在接受吗啡治疗的COPD患者中观察到的喘息改善可能与改善睡眠质量和日常功能相关.
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