相关实验视频
Updated: Jul 1, 2025

05:37
Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
2.2K
围植入炎的新免疫学方面
Bárbara Bellocchio Bertoldo1, Guilherme Oliveira Paulo2, Taíssa Cássia de Souza Furtado3
1Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
Einstein (Sao Paulo, Brazil)
|March 13, 2024
概括
周植入炎与较高的缺氧诱导的HIF-1α水平有关. 这项研究发现,在周植入炎中,HIF-1α,TNF-α和VEGF水平升高,这表明炎症和血管生成增加.
科学领域:
- 口腔生物学 口腔生物学
- 免疫学 免疫学 免疫学
- 生物材料科学是生物材料的科学.
背景情况:
- 周植入体炎与炎症和组织缺氧有关.
- 缺氧可以导致缺氧诱导因子1-α (HIF1-α) 的水平增加.
- HIF1-α 影响血管内皮生长因子 (VEGF) 和炎症性细胞因子的表达.
研究的目的:
- 为了比较HIF1-α,VEGF,TNF-α和IL-10在周围植入物沟液中的水平.
- 调查这些生物标志物与周植入炎存在的关系.
主要方法:
- 分析了40名患者的周植入器沟液 (16名患有周植入器炎,24名没有).
- 对HIF1-α,VEGF,TNF-α和IL-10水平的量化.
主要成果:
- 在患有周植入炎的患者中观察到显著更高的HIF1-α水平 (p=0.0005).
- TNF-α与IL-10 (p=0.0008) 和VEGF (p=0.0246) 有正相关性.
- 在周植入炎组中,在HIF1-α和IL-10之间发现了负相关性 (p=0.0041).
结论:
- 周植入炎中HIF1-α升高可能是炎症诱导的缺氧引起的.
- TNF-α和VEGF之间的正相关性表明增强的促炎活性.
- 需要进一步的研究来阐明围植入炎中复杂的免疫动态.
相关概念视频
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Cell-mediated Immune Responses
68.2K
Overview
68.2K
Bacterial Signaling
32.1K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
32.1K

