在长期使用双酸盐治疗后,非典型的股骨骨折和不典型的股骨骨折的白人绝经后妇女之间,骨基组学上的差异
Shijing Qiu1, Ruban Dhaliwal2,3, George Divine4
1Bone and Mineral Research Laboratory, Henry Ford Health, Detroit, MI 48202, USA.
概括
接受双酸盐 (BPs) 治疗的骨质疏松症患者经历非典型的股骨骨折 (AFFs) 时,骨厚度降低,骨再吸收标记较高. 较长的BP治疗持续时间增加了AFF风险.
科学领域:
- 骨生物学 骨生物学 骨生物学
- 骨质疏松症研究 骨质疏松症研究
- 生物材料科学 生物材料科学
背景情况:
- 抗吸收药物,包括双酸盐 (BPs),对于治疗骨质疏松症至关重要.
- 非典型的股骨骨折 (AFF) 是长期接受高血压治疗的患者的潜在并发症.
- 骨组织形状测量可以提供关于AFF发展背后的机制的见解.
研究的目的:
- 为了研究与没有AFFs的患者之间的过时性结核活检中的骨组织结构测量差异.
- 为了评估骨微观结构,骨周转率和骨质疏松症患者治疗阿伦德罗酸盐的AFF发生之间的关联.
- 为了确定长时间的双酸盐治疗持续时间是否会影响AFF风险.
主要方法:
- 对52名绝经后妇女进行过关骨活检,有 (n=20) 和没有 (n=32) AFF.
- 所有患者都接受了连续的阿伦德罗纳特治疗,持续时间为4至17年.
- 分析了骨组织形态测量终点在无效,皮质内和内皮质包裹中.
主要成果:
- AFF患者的阿伦德罗纳特治疗持续时间明显长 (10.7年而不是8.0年).
- AFF患者在状和皮质内外包中表现出较低的壁厚 (W.Th).
- AFF患者在皮层内表现出较高的骨质细胞表面 (Oc.S/BS) 和侵蚀表面 (ES/BS),骨形成标志物没有显著差异.
结论:
- 接受双酸盐治疗的AFF患者在阴道和皮质包裹中减少了表面骨厚.
- 在AFF和非AFF患者之间,阴茎骨的骨周转率相似.
- 较长的双酸盐治疗持续时间与AFF的可能性增加有关.
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