骨硬化与冠状动脉化之间的关联:一项观察性和孟德尔随机化研究
Haojie Lu1,2, Christine W Lary3, Chani J Hodonsky4
1Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, CA 3000, The Netherlands.
概括
这项研究没有发现骨矿物密度 (BMD) 和冠状动脉化 (CAC) 之间的因果关系. 以前观察到的关联可能是由于其他因素,而不是骨质疏松症直接导致血管化.
科学领域:
- 生物医学研究生物医学研究
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 观察性研究显示,骨矿物密度 (BMD) 和冠状动脉化 (CAC) 之间存在不一致的联系.
- 了解这种关系对于确定骨质疏松症和心血管疾病的共同风险因素至关重要.
研究的目的:
- 调查BMD和CAC之间的观测相关性.
- 评估使用孟德尔随机化 (MR) 和多基因风险评分 (PRS) 的BMD和CAC之间的潜在因果关系.
主要方法:
- 利用来自两个大型基于人口的队列的数据:鹿特丹研究 (1414名参与者) 和弗拉明汉心脏研究 (2233名参与者).
- 采用线性回归用于观测分析和1和2样本的门德尔随机化 (MR) 与逆方差加权 (IVW) 和2阶段最小平方回归用于因果推理.
- 评估了全身,腰椎和大腿部部的BMD,以及CAC测量.
主要成果:
- 在不同骨部位的BMD水平和CAC之间没有发现强有力的观察关联.
- 平均CAC显示在BMD (PRSBMD) 五分之一组的多基因风险评分中均随机分布.
- 无论是1样本或2样本MR分析都没有支持BMD和CAC之间的因果关系.
结论:
- 这项研究不支持一种因果关系,即较低的BMD增加了CAC的风险.
- 据报道,骨硬化和CAC之间的流行病学关联很可能归因于未测量的混因素或共同的潜在病因.
- 研究结果表明,骨质疏松症和血管化可能没有共同的直接因果途径.
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