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石症的定义及其与老年瑞典妇女骨折风险的关联
Anoohya Gandham1,2, Giulia Gregori3, Lisa Johansson3,4
1Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria 3000, Australia.
概括
萨尔科佩尼亚定义和结果联盟 (SDOC) 的定义,侧重于肌肉力量和功能,是唯一与老年女性骨折风险更高相关的定义. 其他定义显示与骨折风险没有显著关联.
科学领域:
- 老年学是一门学科.
- 整形外科 整形外科 整形外科
- 肌肉骨健康 肌肉骨健康
背景情况:
- 标志着肌肉质量和力量的损失的萨尔科佩尼亚,是老龄化人口日益关注的问题.
- 存在不同的术语定义,可能导致与健康结果的不同关联.
- 了解肉症定义与骨折风险之间的联系对于老年人有针对性的干预措施至关重要.
研究的目的:
- 调查瑞典老年妇女中三种不同的肉症定义的流行情况.
- 检查这些肉类症定义与骨折风险之间的关联,包括主要骨质疏松性骨折 (MOF) 和部骨折.
- 根据已确定的骨折风险因素进行调整,包括从骨折风险评估 (FRAX) 工具中获得的风险因素.
主要方法:
- 一组2883名瑞典妇女 (平均年龄77.8岁) 被跟踪了大约6.4年.
- Sarcopenia 用 Sarcopenia 定义和结果联盟 (SDOC),修订的欧洲老年人肉症工作组 (EWGSOP2) 和亚洲肉症工作组 (AWGS) 的标准进行了评估.
- 考克斯回归分析被用来确定死亡率和骨折的危险比率 (HRs),根据年龄进行调整,FRAX变量和大腿T-score.
主要成果:
- 根据定义,肉症的患病率有所不同:4.5% (SDOC),12.5% (EWGSOP2) 和10.3% (AWGS).
- 由SDOC定义的肉类与增加的死亡风险 (HR: 3.41) 和任何骨折 (HR: 1.48) 和MOFs (HR: 1.42) 的更高风险有关.
- 根据EWGSOP2和AWGS的定义,在调整后,sarcopenia与骨折风险增加没有显著联系.
结论:
- SDOC对肉类的定义,包括肌肉强度和功能的测量,与老年女性骨折风险增加有独特的关联.
- 目前的骨折风险评估工具可能无法完全捕捉由肌肉功能定义的肉症所带来的风险.
- 需要进行进一步的研究,以完善肉症的定义及其在预测老年人群中骨折风险方面的临床实用性.
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