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Markus Lenzhofer^1,2, Melchior Hohensinn¹, Veit Steiner¹

¹Department of Ophthalmology and Optometry, Paracelsus Medical University Salzburg, Salzburger Landeskliniken, Salzburg, Austria.

Acta ophthalmologica

|March 13, 2024

概括

在5年内,XEN45植入物有效降低眼内压 (IOP) 和开角青光眼患者的药物需求. 结合XEN45和白内障手术的成功率高于XEN45单独的成功率.

科学领域:

眼科医生眼科眼科
玻璃眼的手术玻璃眼的手术
最少侵入性玻璃眼外科手术

背景情况:

开角玻璃眼 (OAG) 是一种渐进的视神经病变,其特征是眼内压力升高 (IOP).
有效的内视压缩对于预防OAG患者的视力损失至关重要.
XEN45植入物是一种用于IOP管理的微创装置.

研究的目的:

在OAG患者中评估XEN45植入物的外科成功和疗效.
为了比较XEN45植入单独与白内障手术结合的结果.
为了评估植入后长达五年的结果.

主要方法:

一个前性,观察性,单心试验,涉及157名OAG患者的192只眼睛.
患者接受了单独的XEN45植入物 (单独手术) 或联合XEN45和白内障手术.
在5年内分析了手术成功,二次内血压降低手术的时间,内血压和药物使用情况.

主要成果:

在5年后观察到显著的IOP降低 (48%) 和药物减少 (50%) (p < 0.001).
与单独手术相比,联合手术的成功率更高 (IOP ≤18 mmHg:63%;IOP ≤12 mmHg:37%) 与单独手术相比 (36%;13%) (p=0.035,0.028).
单独的XEN45程序具有较高的二次IOP降低程序率 (HR:2.02,p=0.04).

结论:

在OAG中,XEN45植入物对中期IOP和药物减少是有效的.
结合XEN45和白内障手术的成功率比XEN45单独的成功率更高.
根据文献比较,管切除术可能提供更高的无药成功率.

关键词:

这就是MIGS.一个XEN45格洛科马凝微型支架.有效性有效性有效性.在中期的中期期内.成功的成功的成功的成功.

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