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一种苦味物质 - - 酸对胰腺激素分泌的作用
Weikun Huang1,2, Stephanie E O'Hara3,4, Cong Xie1
1Centre for Research Excellence in Translating Nutritional Sciences to Good Health, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
American journal of physiology. Endocrinology and metabolism
|March 13, 2024
概括
苦味物质丹酸 (DB) 刺激胰腺小岛的胰岛素,葡萄糖和体静止素分泌,而不依赖于葡萄糖. 高剂量的DB诱导了亡,这表明苦化合物对葡萄糖平衡有潜在的负面影响.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 细胞生物学 细胞生物学
背景情况:
- 苦味受体 (BTR) 信号影响肠道荷尔蒙和葡萄糖平衡.
- BTR信号对胰腺小岛激素分泌的影响在很大程度上仍未被描述.
研究的目的:
- 研究一种苦味物质酸 (DB) 对来自小鼠胰岛和INS-1 832/13细胞的激素分泌的影响.
- 阐明DB诱导的激素分泌背后的机制及其对小岛细胞活性的潜在影响.
主要方法:
- 治疗小鼠胰腺小岛和INS-1 832/13细胞,其DB的度不同.
- 测量胰岛素,葡萄糖和体静止素分泌.
- 评估KATP通道活动,T2R信号和GLP-1释放.
- 在DB暴露后对细胞亡的评估.
主要成果:
- DB (0.5-1毫米) 在低 (2.8毫米) 和高 (16.7毫米) 的葡萄糖度中增加了胰岛素分泌.
- 通过DB刺激的胰岛素分泌涉及KATP通道的关闭,T2R信号的激活,以及肠道GLP-1的释放.
- DB还增强了葡萄糖和体静止素的分泌,其机制需要进一步研究.
- 高剂量的DB (5mM) 在胰腺小岛中诱导显著的细胞亡.
结论:
- 苦味物质DB强化了独立于葡萄糖水平的岛屿激素分泌 (胰岛素,葡萄糖,体静止素,GLP-1).
- 胰岛素释放的增强由KATP道关闭,T2R信号传递和内链GLP-1介导.
- 高剂量的DB暴露导致胰腺小岛细胞亡.
- 临床上使用苦味物质用于葡萄糖平衡,可能会产生超越肠道的意外不良影响.
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