在VV116与尼尔马特雷尔维尔-里托纳维尔治疗后的COVID-19复苏:一项随机临床试验
Zhitao Yang1, Yu Xu2,3, Ruizhi Zheng2,3
1Emergency Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
JAMA network open
|March 13, 2024
概括
抗病毒治疗后的COVID-19反弹是常见的. 这项研究发现,在轻度至中度病例中,VV116和尼尔马特里尔维尔-里托纳维尔的病毒载荷和症状反弹率相似.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 临床药理学 临床药理学
背景情况:
- 广泛使用抗SARS-CoV-2药物导致观察到治疗后病毒载量反弹.
- 了解治疗出现的病毒动态对于管理COVID-19至关重要.
研究的目的:
- 为了比较5天VV116疗程后轻度至中度COVID-19患者的病毒载荷反弹 (VLR) 和症状反弹的发生率与nirmatrelvir-ritonavir.
主要方法:
- 一个单中心,调查者盲目的随机临床试验在中国上海进行.
- 患有轻度至中度COVID-19的成年患者接受了VV116或nirmatrelvir-ritonavir治疗5天.
- 主要结局是病毒载量反弹;次要结局包括症状反弹和反弹时间,随访直到第60天.
主要成果:
- 病毒载量反弹发生在VV116组的20.0%和nirmatrelvir-ritonavir组的21.7% (P=.70).
- 症状复发在VV116组的25.6%和涅马特里尔维尔 - 里托纳维尔组的24.5% (P=.82) 观察到.
- 病毒全基因组测序证实了在反弹病例中相同的SARS-CoV-2血统.
结论:
- 病毒载量反弹和症状反弹在VV116和nirmatrelvir-ritonavir两种标准的5天治疗疗程后经常发生,用于轻度至中度的COVID-19.
- 对延长治疗持续时间的进一步调查可能是有必要的,以减轻反弹事件.
- 这些发现有助于理解COVID-19管理中的抗病毒疗效和治疗后病毒动态.
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