相关实验视频
Updated: Jul 1, 2025

12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
34.5K
长非编码RNA对Th17/Treg分化和失衡的调控作用
Reza Dabbaghipour1, Elham Ahmadi2, Mona Entezam3
1Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran AND Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. dabaghipourreza@gmail.com.
Iranian journal of allergy, asthma, and immunology
|March 13, 2024
概括
长非编码RNAs (LncRNAs) 通过调节T辅助细胞17 (Th17) 和调节T细胞 (Treg) 来显著影响免疫反应. 对于与Treg/Th17不平衡相关的疾病,特别是癌症,LncRNA具有作为生物标志物和治疗点的潜力.
科学领域:
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 长非编码RNAs (LncRNAs) 是基因表达的关键调节者.
- 免疫反应涉及亲炎性T辅助17 (Th17) 细胞和抗炎性调节性T细胞 (Treg) 之间的平衡.
- Treg/Th17比率的不平衡与各种人类疾病有关.
研究的目的:
- 审查LncRNAs与Th17/Treg平衡之间的关联.
- 突出LncRNAs作为预后和诊断生物标记物的潜力.
- 确定LncRNAs作为Th17/Treg失调的疾病的治疗点,特别是癌症.
主要方法:
- 关于LncRNAs和免疫调节的科学研究的文献综述.
- 对将LncRNA表达与Th17/Treg细胞群相关联的研究进行分析.
- 综合有关LncRNAs在疾病发病和治疗潜力的作用的发现.
主要成果:
- 已经确定了许多调节Treg/Th17细胞分化和功能的LncRNAs.
- 特定LncRNAs的变化与各种病理条件中的Th17/Treg失衡有关.
- 作为疾病进展和治疗反应的指标,LncRNAs显示出希望.
结论:
- 在复杂的免疫反应调节中,LncRNAs是关键的参与者.
- 了解LncRNA介导的Treg/Th17调制为开发新型诊断和预后生物标志物提供了机会.
- 针对LncRNAs为特征是Treg/Th17失衡的疾病提供了一个有前途的治疗策略,特别是在瘤学中.
相关概念视频
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
Regulation of Expression at Multiple Steps
904
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
904
Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Types of RNA
5.8K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.8K

