在中度至重度喘儿童中比较布德索尼德和流 propionate:试点随机对照试验
Mansour Sadeghzadeh1, Parisa Khoshnevisasl2, Akefeh Ahmadiafshar3
1Department of Pediatrics, Zanjan University of Medical Sciences, Zanjan, Iran. sadeghzadeh@zums.ac.ir.
Iranian journal of allergy, asthma, and immunology
|March 13, 2024
概括
与布德索尼德 (Bud) 相比,西松 propionate (FP) 显著改善了喘控制测试成绩,并减少了与中度至重度喘儿童的救援药物的使用. 在治疗儿科喘症状方面,FP表现出卓越的疗效.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 临床药理学 临床药理学
背景情况:
- 儿童喘管理需要有效的抗炎策略.
- 吸入性皮质类固醇 (ICS) 是慢性喘的基础疗法.
- 对比不同ICS的疗效对于优化治疗至关重要.
研究的目的:
- 为了比较流他 propionate (FP) 和budesonide (Bud) 在中度至重度喘儿童的疗效.
- 评估FP与Bud对喘控制,临床症状和救援药物使用的影响.
- 评估儿童喘患者在3个月的治疗结果.
主要方法:
- 一项涉及50名中度至重度喘儿童 (4至7岁) 的开放性研究.
- 随机分配,每天接受FP250微克或Bud400微克,持续3个月.
- 每月评估喘控制测试 (ACT) 成绩,临床症状,药物坚持和救援吸入器使用情况.
主要成果:
- 在FP和Bud两组,ACT分数,夜间症状和咳率均显著改善.
- 与布德索尼德组 (22.48±4.12) 相比,化 propionate 组的平均 ACT 评分 (24.84±2.67 在 3 个月内) 更高.
- 在整个研究期间,与布德索尼德相比,氨酸显著降低了对萨尔布塔摩尔 (救援药物) 的需求.
结论:
- 氨酸 (250毫克) 在改善中度至重度喘儿童的喘控制和减少救援药物需求方面比布迪索尼德 (400毫克) 更有效.
- FP在提高喘控制测试得分和减少萨尔布塔摩尔使用方面表现出卓越的有效性.
- 这些发现表明FP可能是优化喘管理的首选治疗方案,在这个儿科群体.
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