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Updated: Jul 1, 2025

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
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Published on: January 5, 2016

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帕金森病的发病因子:从单源家族性PD的线索到生物标志物

Nobutaka Hattori1,2,3,4,5, Manabu Funayama6,7,8, Yuzuru Imai6,9

  • 1Department of Neurology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8421, Japan. nhattori@juntendo.ac.jp.

Journal of neural transmission (Vienna, Austria : 1996)
|March 13, 2024
PubMed
概括

帕金森 (PRKN) 基因的发现彻底改变了对帕金森病 (PD) 机制的理解,揭示了与线粒体健康和蛋白质溶解系统的联系. 研究确定了帕金因通路中的CHCHD2和普罗萨素 (PSAP),有助于早期诊断PD.

关键词:
在PARK2中.自-溶酶体通路自-溶酶体通路生物标志物生物标志物lysosome 是一个溶解体.线粒体中的线粒体.线粒细胞衰变 - - 线粒细胞衰变 (mitophagy) 是一种停车场可以停车.乌比奎丁保护酶体通路

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