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在Omicron变种期间,希腊儿童中SARS-CoV-2血清流行率

Dimitra Dimopoulou¹, Despoina Sotiri², Dimitra Kousi³

¹Second Department of Paediatrics, School of Medicine, National and Kapodistrian University of Athens, 'P. and A. Kyriakou' Children's Hospital, Thivon and Leivadias, Athens, 30601, Greece.

European journal of pediatrics

|March 13, 2024

概括

在Omicron变种激增期间,SARS-CoV-2的血清阳性在儿童中显著增加.由于更高的传染性. 1-4岁的幼儿显示出较高的抗体反应,而婴儿的抗体标位较低,需要持续监测.

科学领域:

* 儿童传染病儿童传染病
* 免疫学免疫学
* 流行病学流行病学

背景情况:

* Omicron变种的高传染性引起了人们对其对儿科SARS-CoV-2血清阳性影响的担忧.
* 关于Omicron对儿童抗体水平的特定影响的证据有限.
*了解不同变体和年龄组的血清流行对于公共卫生至关重要.

研究的目的:

* 为了评估在不同的Omicron子周期期间儿童的SARS-CoV-2血清流行率.
* 分析各种儿科年龄组的抗体反应 (抗Spike和抗核体IgG,中和抗体).
*评估Omicron变种对儿科血清阳性趋势的影响.

主要方法:

* 在7所希腊大学医院进行的前性多中心血清流行研究 (2021年11月至2022年8月).
* 为非COVID-19原因住院或在门诊诊所看病的2127名儿童的注册.
* 血清中和抗体 (NAbs),抗Spike (anti-S) IgG和抗核体 (anti-N) IgG的实验室评估.

主要成果:

* 在研究期间,抗N IgG血清阳性从17.8%上升到40.7%,然后略微下降至36.7%.
*抗S IgG血清阳性呈现出一致的上升趋势,从34.8%上升到80.7%.
* 1-4岁儿童的抗N IgG标位明显高于婴儿 (0-1岁). 婴儿表现出较低的抗S IgG和NAb标位相比较于年长的孩子,特别是免疫力低下的人.

结论:

* 在Omicron期间,儿科SARS-CoV-2血清阳性显著增加,这归因于传染性增加.
*幼儿 (1-4岁) 显示出潜在的更强抗体反应,而婴儿显示出较低的抗体标位.
* 对儿童的持续血清流行监测对于跟踪SARS-CoV-2传播和告知公共卫生战略至关重要.

关键词:

在 COVID-19 疫情中,孩子孩子孩子孩子这就是Omicron.这就是SARS-CoV-2病毒.血清流行病学血清流行病学血清的流行程度是如此.变种变种变种变种

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