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Updated: Jul 3, 2026

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高流动性组盒蛋白 (HMGB1):糖尿病脑病的潜在治疗标

Udit Kumar Dash1, Debashree Mazumdar1, Santosh Singh2

  • 1Biochemistry and Molecular Biology Laboratory, Department of Zoology, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, 495009, India.

Molecular neurobiology
|March 13, 2024
PubMed
概括

高流动性B1组 (HMGB1) 蛋白质通过促进炎症和神经毒性,有助于糖尿病脑病 (DE). 了解HMGB1的理解

关键词:
糖尿病是一种糖尿病.糖尿病脑病变 - 糖尿病脑病变这就是HMGB1的特点.高流动性组盒子蛋白质 高流动性组盒子蛋白质神经退行性疾病 神经退行性疾病

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...