药物相互作用与住院患者的实际伤害:一项多中心研究检查了电子药物系统实施前和后的流行率
Ling Li1, Jannah Baker2, Renee Quirk3
1Faculty of Medicine, Health and Human Sciences, Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Road, Sydney, NSW, 2109, Australia. ling.li@mq.edu.au.
Drug safety
|March 13, 2024
概括
大多数住院患者会出现潜在的药物相互作用 (pDDI),但很少有临床相关性. 电子药物管理 (eMM) 减少了临床相关DDI的同时使用,但警报的价值需要进一步研究.
科学领域:
- 药理学 药理学是指药理学的学科.
- 医疗信息学 医疗信息学
- 患者安全 患者安全
背景情况:
- 药物相互作用 (DDI) 存在风险,可能降低治疗效果并对患者造成伤害.
- 评估潜在的DDI (pDDI),临床相关的DDI (cDDI) 和实际危害的患病率对于患者安全至关重要.
- 电子药物管理 (eMM) 对DDI和患者伤害的影响需要调查.
研究的目的:
- 确定住院患者中pDDI,cDDI和实际伤害的患病率.
- 评估向eMM过渡对DDI发生和患者伤害的影响.
- 分析已识别的DDI的临床相关性.
主要方法:
- 从前后对照研究中对对照组的二次分析.
- 在eMM实施之前和之后,在三个澳大利亚医院进行了回顾性图表审查.
- 专家小组对DDI的危害评估和分类,在eMM系统中没有DDI警报.
主要成果:
- 70.1%的入院患者患有pDDI,42.6%患有cDDI,0.9%患有实际伤害.
- 在15860个确定的pDDI中,有27.0%被归类为cDDI.
- 在eMM实施后,参与cDDI的药物的同时使用减少了44%.
结论:
- 虽然大多数患者会遇到pDDI,但少数患者在临床上是相关的.
- 伤害的发生率很低,这表明在DDI决策支持警报的普遍价值方面应该谨慎.
- 实施eMM与减少潜在有害药物相互作用的同时使用有关.
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