在叶中认知表现和工作记忆的功能相关性:基于任务和休息状态fMRI的见解
Alfonso Fajardo-Valdez1, Vicente Camacho-Téllez1,2,3, Raúl Rodríguez-Cruces1,4
1Institute of Neurobiology, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro, México.
PloS one
|March 13, 2024
概括
叶 (TLE) 破坏大脑网络,影响认知. 在TLE患者中异常的功能连接与认知缺陷相关,特别是在工作记忆中,这表明大脑网络的广泛参与.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 的研究研究.
背景情况:
- 叶 (TLE) 是一种常见的,难以治疗的形式.
- 除了发作之外,TLE还涉及影响认知的广泛的大脑异常.
- 现有的研究往往侧重于全球网络或特定的认知功能.
研究的目的:
- 为了将全脑功能连接 (FC) 异常与TLE的认知表现联系起来.
- 调查FC变化如何影响TLE中的前端-平行工作记忆 (WMem) 网络.
- 了解大脑网络中断和TLE认知变异之间的关系.
主要方法:
- 评估了31名TLE患者和35名健康对照.
- 使用认知测试,静止状态fMRI (RS-fMRI) 和基于任务的fMRI (斯特恩伯格的WMem任务).
- 在WMem任务中使用全脑FC分析,以种子为基础的连接性,并检查了前额-双侧活动.
主要成果:
- TLE患者在各个领域表现出认知缺陷,具有显著的可变性.
- 在TLE中,功能网络 (DMN,TPN) 的破坏与认知表现相关.
- 在TLE患者的WMem任务中观察到异常的前额-双肩活动和连接性.
结论:
- 在TLE中认知障碍的严重程度与异常大脑活动和连接性的程度有关.
- 广泛的功能网络中断有助于TLE的认知障碍.
- 不同的协同激活模式可能表明TLE患者的补偿机制.
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