最大限度地坚持抗生素并最大限度地减少抗生素治疗时间:一个多学科机构创伤湾协议,用于开放骨折中单一抗生素预防
Erick Heiman1, Joss Delaune2, Ian S Hong1
1Division of Orthopaedic Trauma and Adult Reconstruction, Department of Orthopaedic Surgery, Jersey City Medical Center - RWJBarnabas Health, Jersey City, NJ.
Journal of orthopaedic trauma
|March 13, 2024
概括
一个新的协议显著减少了开放骨折的抗生素施用时间,从53%提高了遵守96%. 这种多学科的方法优化了对有开放骨折的创伤患者的护理.
科学领域:
- 创伤外科 手术 创伤外科
- 预防传染病 预防传染病
- 临床协议优化 临床协议优化
背景情况:
- 及时服用抗生素对于预防开口骨折 (openFx) 感染至关重要.
- 抗生素预防方案的变化可能导致创伤激活期间的治疗延迟.
研究的目的:
- 评估一个多学科的机构协议在优化开放骨折的抗生素 (Abx) 给药时间的有效性.
- 为了评估在创伤激活期间的Abx预防合规性的改善.
主要方法:
- 在II级创伤中心的回顾性前后研究设计.
- 在 (前组) 和 (后组) 实施协议之前治疗的患者进行了比较.
- 包括患者怀疑openFx经历创伤激活,不包括尾骨架骨折.
主要成果:
- 该方案显著减少了从87.9分钟到22.2分钟 (P < 0.001) 的Abx给药的平均时间.
- 在60分钟内服药Abx的遵守率从53%增加到96% (P<0.001).
- 后期分析证实,该研究的功率为92%以检测出这一显著差异.
结论:
- 一个多学科的机构协议是有效的优化开放骨折抗生素的管理时间.
- 该协议可以在其他创伤中心实施,以改善开放骨折患者的治疗结果.
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