疫苗接种或感染引起的Mpox特异性免疫反应在艾滋病毒感染者身上
Eva Grüner1, Marica Grossegesse2, Daniel Stern3
1Department of Infectious Diseases, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.
The Journal of infectious diseases
|March 13, 2024
概括
在患有人体免疫缺陷病毒 (PWH) 的人群中,Mpox感染和天花疫苗接种 (改性疫苗安卡拉) 引起了强大的细胞和幽默免疫反应. 儿童天花疫苗接种可以提供对mopox病毒的持久保护,即使在PWH.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 人类免疫缺陷病毒 (PWH) 感染者在mopox爆发期间面临更高风险.
- 了解PWH的免疫反应对于疫情控制和预防至关重要.
研究的目的:
- 调查与男性发生性关系的男性 (包括PWH) 中对mopox感染和天花疫苗接种的细胞和幽默免疫反应.
- 评估天花疫苗接种诱导的对mopox病毒免疫的交叉反应性和持久性.
主要方法:
- 研究了一组与男性发生性关系的男性的免疫反应,包括PWH,在mopox感染或修饰疫苗安卡拉 (MVA) 疫苗接种后.
- 分析了B细胞,CD4T细胞和CD8T细胞的反应.
主要成果:
- 无论是mopox感染还是MVA疫苗接种,都在PWH中诱导了mopox特异性免疫反应.
- 之前在儿童时期接种了天花疫苗的个体对mopox病毒表现出交叉反应性免疫反应.
- 免疫反应涉及B细胞,CD4 T细胞和CD8 T细胞.
结论:
- 麻疹疫苗接种,包括儿童疫苗接种,可以引起对mopox病毒的交叉反应性免疫力.
- 对mopox的免疫反应是持久的,甚至在受控HIV的PWH中也存在.
- 这些发现提高了对脊髓灰质炎病毒免疫力和疫苗接种策略的理解.
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